Police are appealing for witnesses and dashcam footage after a fatal crash on the A53 Buxton to Leek Road.
The collision, involving a Fiat 500 and a Peugeot 307, occurred near to the Winking Man pub just after 5pm on Saturday.
A 64-year-old woman, a passenger in one of the vehicles, was sadly pronounced dead at the scene.
Woman dies in crash on A53 Buxton to Leek road
Staffordshire Police said: "The family of the woman have been notified and are currently being supported by specially-trained officers.
Formal identification is due to take place tomorrow (November 13). "
Three other people were taken to hospital, and their condition is described as stable. .
Anyone who witnessed the collision or has dashcam footage is asked to call Staffordshire Police on 101 quoting incident number 547 of November 10.