More than two thirds of people aged 65 to 69 have now had their vital first dose, after invites went out a few weeks ago.
Anyone who is aged 65 or over can get an appointment in one of the vaccination centres by booking through the national booking service, as the NHS looks to help as many people in this age group get their jab and make use of available doses.
The fresh call to those aged 65 to 69 comes as invites for people aged 64 are landing on doormats across the region, with this group of nearly half a million people nationwide set to be asked initially to book a slot at one of the larger vaccination centres.
NHS Derby and Derbyshire CCG executive medical director Dr Steve Lloyd said: “NHS staff, volunteers and other partners across Derbyshire have done an incredible job so far delivering the largest vaccination drive in our history, at the same time as dealing with high levels of Covid-19 hospital patients.
“To the small proportion of people who have been invited but not come forward yet, I would urge you to do so.
"Vaccines are the best weapon we have in the fight against coronavirus and local services are going to great lengths to ensure that local people can get this protection in a safe and convenient place.
“And to the wider public, NHS staff need you to continue to play your part too.
"That means unless you are in the groups being invited now, please don’t contact the NHS to seek a vaccine, we will contact you when it is the right time.
"When we do contact you, please attend your booked appointments at exactly the time you’re asked to and whether you have had your vaccine or not, please continue to follow all the guidance in place to control the virus and save lives.”
People who have received a letter can log on to the national booking service at www.nhs.uk/covid-vaccination and choose from more than 20 sites across Derbyshire.
Anyone unable to book online can call 119 free of charge, anytime between 7am and 11pm seven days a week.