The stretch of road – which runs through the infamous Snake Pass - was ranked as having the highest number of road accidents causing casualties in the entire borough during the four-year period.
After the A57 the A6 was named as High Peak’s second-most dangerous – with 74 collisions over the same time period.
High Peak’s third-most perilous highway was the A624 – with 64 accidents.
However the borough’s least-deadly A roads were the A6016 – with just two crashes – and the A514 with only one.
The scary findings were uncovered by an analysis of the Department for Transport’s accidents data.
High Peak roads were ranked 239th most dangerous out of 380 British local authorities in terms of crashes – with 847 between 2014-2018 – while nearby Derbyshire Dales came in at 121.
The High Peak’s 10 most dangerous roads are as follows:
A57 – 137 accidents A6 – 74 accidents A624 – 64 accidents A628 – 58 accidents A5004 – 39 accidents A515 – 37 accidents B5470 – 36 accidents A53 – 26 accidents A6015 – 25 accidents B6105 – 17 accidents
While the number of accidents causing death or injury has fallen by a sixth in the past five years road safety charity Brake said more should be done to catch and punish dangerous drivers.
The Department for Transport (DfT) said it was making improvements to some of the country’s most dangerous stretches of road.
A spokesperson for Brake said there were steps drivers could take to prevent crashes - such as slowing down, not using mobile phones when driving and getting their eyesight tested regularly.
But they added there needed to be ‘greater investment in road traffic enforcement so that people who do drive dangerously and break the law, endangering themselves and all other road users are caught and punished’.
The DfT said allocation of crime-fighting resources was a matter for chief constables as well as police and crime commissioners.
The department said busier roads would have a higher number of accidents but ‘vital improvements’ were being made to roads.
A spokesperson said: “We are committed to improving road safety across the country and the Safer Roads Fund will provide vital improvements to the 50 most dangerous stretches of road in England.
“In addition we launched a Road Safety Action Plan last year which set out more than 70 measures to reduce the number of people killed and injured on our roads.”