Stroud in Gloucestershire was named the overall winner, as it “has all the basics covered in perfect style, but even better it has a strong community spirit and knows how to celebrate all things local”.
Sign up to our daily Buxton Advertiser Today newsletter
The i newsletter cut through the noise
The Sunday Times says Edale is "a farming community first and foremost — and it can feel heroically remote".
Eight places were then nominated for each UK region, with Edale named among the best places to set up home in the Midlands, behind regional winner Stamford.
The Sunday Times said: “In the Midlands, there’s inspiring urban edge on offer in Coventry and Birmingham, but unpretentious rural living is the main attraction in the Midlands, whether in beautiful Stamford, rugged Edale or the muddy lanes of Rutland.”
Other places to feature across the UK include the cities of York and Leeds, north-west winner Altrincham and north and north-east winner Ilkley, West Yorkshire.
The guide hails Edale's "energetic, creative community spirit", as well as the countryside which, it says, means "work-from-homers will be queuing the length of this valley for the chance to set up HQ in one of its handsome stone houses".
In these confusing and worrying times, local journalism is more vital than ever. Thanks to everyone who helps us ask the questions that matter by taking out a subscription or buying a paper.
The Sunday Times says: "Edale is from 35 minutes to Sheffield and from 44 minutes to Manchester by train, much faster than in the car. Save the car for short journeys — it takes about an hour to reach the M1 or the M6."
The award judges say Edale is ideal if "you want impeccably connected real country living".
The Sunday Times says the scenery around Edale is a big draw.
The Sunday Times says there aren't many better sights than Kinder Scout and Mam Tor "and there’s nowhere better for a weekend hike than among the dramatic rock formations that line the edges of the Kinder plateau" - but warns weekend hikers "can clog up the lanes with parked cars".
"Independent and lively" Stroud, in Gloucestershire, was named the best place in the UK to live. The Sunday Times said: "The schools are excellent, as are the transport links and the surrounding Cotswold countryside."
The Lincolnshire town of Stafford was named the best to live in the Midlands by The Sunday Times, which said: "Thanks to a stubborn marquess, this former wool town has kept its period charms, but its broadband brings it bang up to date."
Birmingham was named as one of the eight best places to live in the Midlands, particularly the elegant, old-fashioned suburb of Bournville and its neighbour Stirchley, "the rough-and-ready new kid, full of energy with no respect for tradition".
The Cotwold 'gem' of Ilmington, Warwickshire, was also named among the best Midlands places to live, alongside the "upwardly mobile" Coventry suburb of Earlsdon.
Shakespeare's Warwickshire birthplace also made the Midlands list, as a well-connected, pretty riverside town.
Rutland was named among the best eight places to live in the Midlands, with its "rolling green fields and pretty villages" singled out.
The Sunday Times said: "Indie shops and wellness workshops have brought this hillside town to new heights."