GNE closed the gap on leaders Runcorn Linnets to single figures with a comfortable victory by the seaside on Tuesday evening.
Their tenth league victory in a row was effectively sealed after 23 minutes.
The Hillmen started very brightly and had already been denied a very strong penalty claim and had gone close from a corner when taking an 11th minute lead.
The ball came to Mark Reed at the edge of the area and he curled a shot onto the inside of the post that nestled in the goal.
The lead was doubled on 22 when Eddie Moran played the ball wide to Kelvin Lugsden, whose cross evaded everyone and sailed into the net.
A minute later it was 3-0 when Lugsden was felled in the area and Eddie Moran despatched the spot-kick.
It was the dream start for North End, the points pretty much wrapped up early, and they nearly made absolutely sure on half-time as Matt Russell hit the post and the Blackpool goalkeeper then pulled off a miraculous save from Sam Hind’s rebound header.
AFC gave themselves some hope shortly after the break when Kurt Willoughby scored an outstanding free-kick that cleared the wall and then dipped under the bar.
However the three goal advantage was restored on 78 when Kelvin Lugsden put in a delicious whipped cross that Reed headed home.
Hind then hit the post with a low drive, before Reed’s low cross from the right in the game’s dying embers was turned into his own net by Marc Taylor.
After the excitement of Saturday’s St Austell victory, GNE could have been distracted by the second leg this Saturday - but there was never any realistic chance of this determined squad letting that happen.