The A6015 New Mills Road, in Hayfield, will be closed by Derbyshire County Council from October 27 to 31 between 7pm and 11pm.
The road will be shut from the A624 junction for a distance of 100 metres to the west, to allow for carriageway resurfacing works.
A diversion will be put in place via the B6101, the A57 and the A6016.
Access will be maintained, whenever reasonably possible, on the affected length of road.
The road will re-open as soon as the work is finished, which may be earlier than advertised.
Derbyshire County Council apologises for any inconvenience caused while work takes place. Anyone needing further information should ring Call Derbyshire 01629 533190.