Firefighters are currently battling a 'substantial' grass fire at the Roaches.
Staffordshire Fire and Rescue Service said there are currently ten appliances in attendance at the scene of the blaze at Upper Hulme, in the Staffordshire Moorlands, along with water carriers from Cheadle and Buxton.
The fire, which was reported at 1.28pm on Thursday afternoon, involves an area of approximately 500 square metres, and rangers and firefighters are using beaters and water jets to bring it under control.
A fire service spokesperson said the area was being evacuated with the help of Staffordshire Police and the force's helicopter, which is checking the area for members of the public.
One resident has been treated by West Midlands Ambulance Service for smoke inhalation.
Deputy Chief Fire Officer Rob Barber said: "Roach Road and the Roaches area is currently closed and we are urging people to avoid the area to allow the crews to continue their work.
"We are working closely with our partners to minimise the amount of damage caused by this fire and we are expecting to be here for some time.
"At this time the cause of the fire is unknown and our focus is on safely containing the fire."
Due to the large amounts of smoke, residents in the vicinity are being advised to keep doors and windows closed.
A spokesperson for Staffordshire Wildlife Trust added: "Fire crews are dealing with a substantial fire at our Roaches nature reserve.
"Whilst they work to bring the fire under control please stay clear of the area.
"We'd like to thank everyone in advance for their cooperation."