Officers are appealing for help to trace 59-year-old Donna Dakin who is missing from her home in Ockbrook.
Mrs Dakin left her home at about 11am today (Sunday November 29) and is thought to be driving a red Audi TT registration number KP55 DRV.
There is a possible sighting of her in the area of Castleton, heading towards Sheffield, at 4pm today.
She is five feet six inches tall, with light brown collar length hair. She is probably wearing jeans.
If you have any information please call 101 quoting the incident number 403 of 29th November 2015.