The A53 Buxton Road was closed at Flash after a crash this morning – amid reports of heavy snow on the route.
The incident was near the Knights Table pub between Longnor Road and Brown Lane.
Police said both sides of the carriageway were affected and there was heavy congestion.
There is no immediate word on the seriousness of the crash or any injuries.
A Staffordshire County Council spokesman said its gritters are out in the area and urged motorists to drive with extra care.